Natural Health & Wellness

What Vitamins Help Restless Leg Syndrome? 15 Vitamins & Supplements That Support RLS

What Vitamins Help Restless Leg Syndrome? 15 Vitamins & Supplements That Support RLS TheWellthieone

Your partner has been mentioning that they are not getting good sleep lately because your leg seems to be moving most of the night. If you’ve been diagnosed with restless leg syndrome, which is also referred to as RLS, then you’re likely looking for ways to improve your condition.

If you are interested in taking a look at more natural solutions and avoiding pharmaceuticals if you can, we hope you will find the following extensive list of natural vitamins and supplements helpful.

Fortunately, there are a number of vitamins and supplements that have been shown to be helpful in treating RLS, as well as helping to improve your overall health and well-being.

What is restless leg syndrome?

Restless leg syndrome (RLS), also known as periodic limb movement disorder (PLMD), is a condition characterized by repetitive and incessant movements of the legs. These movements can be felt at any time, but are most commonly experienced during sleep. Although there is no cure for RLS, treatments may help manage its symptoms.

Some popular conventional pharmaceutical treatments involve prescription medications such as clonazepam or diazepam, which work to calm the patient down. Taking these drugs exposes the patient to a long list of side effects. This article will focus on some effective natural supplement strategies you can take to reduce and manage restless leg syndrome. Keep reading to learn more about what they are and what these natural supplements can do for you.

Causes of Restless Leg Syndrome (RLS)

There are several potential causes of RLS, including:

  • central nervous system abnormalities
  • dehydration
  • low levels of omega-3 fatty acids in the blood
  • Low levels of several different vitamins are detailed below.
  • other unique medical conditions

Restless leg syndrome can be managed naturally through supplements. Treatment typically includes lifestyle changes such as drinking plenty of water and consuming high-quality vitamins and supplements.

We’ve put together a list of the most helpful supplements to take to get your restless leg syndrome under control, leading you and your partner to much better-quality sleep each night.

We’ve also found the best brand for each one based on purity, quality, source of ingredients, and value and included them within the list.

Here is a list of the best natural vitamins and supplements that can be taken to manage restless leg syndrome.


Vitamin B6 

Vitamin B6 is essential for the body’s function as a co-factor in red blood cell production and DNA methylation. It has also been shown to help reduce inflammation and nerve pain symptoms associated with RLS.

NOW Supplements, Vitamin B-6 (Pyridoxine HCl) 100 mg

NOW Supplements, Vitamin B-6
NOW Supplements, Vitamin B-6


This nutrient helps regulate blood sugar levels, which can help control brain fog and fatigue related symptoms of the disorder. 

Nutricost Niacinamide (Vitamin B3) 500mg

Nutricost Niacinamide (Vitamin B3)
Nutricost Niacinamide (Vitamin B3)


Magnesium is an important mineral that helps to manage the symptoms of restless leg syndrome (RLS). People with RLS often experience a constant feeling of restlessness, which can be difficult to control. Magnesium deficiency can lead to increased muscle spasm and cramps, making it difficult for people suffering from RLS to get any sleep at all.

Nature’s Bounty Magnesium, Bone and Muscle Health

Nature Bounty Magnesium
Nature Bounty Magnesium

Vitamin D3

Vitamin D3 is a vitamin that has been shown to help manage the symptoms of restless leg syndrome (RLS). Research suggests that people who have low levels of vitamin D3 are more likely to experience RLS, and that supplementation with this nutrient can improve their symptoms.

Vitamin D3, 4000IU

Vitamin D3, 4000IU
Vitamin D3, 4000IU

What does the research say about how vitamin D3 works?

 Studies suggest that vitamin D 3 helps decrease inflammation and pain in the calf muscles, which is why it may be helpful for managing RLS. Additionally, supplemental doses of this nutrient appear to improve nerve function and blood flow in these areas. Taken together, these findings suggest that supplementing with Vitamin D 3 may be an effective way to manage RLS symptoms.


Zinc is a mineral that is essential for the body, and it plays an important role in managing the symptoms of restless leg syndrome (RLS). 

Zinc helps regulate nerve function, which can help reduce the frequency and intensity of RLS symptoms. It also helps to improve blood flow to your feet, which may help relieve some of the discomfort associated with RLS.

Nature Made Zinc 30 mg, Dietary Supplement for Immune Health and Antioxidant Support

Nature Made Zinc 30 mg
Nature Made Zinc 30 mg

Omega-3 fatty acids

Omega-3 fatty acids are essential for the health of your brain and body, so it’s no surprise that they can help manage the symptoms of RLS.

A study published in the journal Advances in Neurology found that participants who took omega-3 supplements experienced improved sleep quality, decreased night time awakenings from restless legs syndrome episodes, and reduced overall anxiety levels. The researchers also noted a reduction in inflammation markers in the blood of participants who supplemented with omega-3s compared to those who didn’t.

Nordic Naturals Ultimate Omega, Lemon Flavor – 90 Soft Gels – 1280 mg Omega-3 

Nordic Naturals Ultimate Omega
Nordic Naturals Ultimate Omega


Calcium is necessary for the most efficient absorption of all of the other vitamins and minerals that you take. 

Nature Made Calcium 600 mg with Vitamin D3, Dietary Supplement for Bone Support

Nature Made Calcium
Nature Made Calcium


Probiotics are microorganisms that help improve health and body function. They can be found in food and supplements. There is a growing evidence base showing that probiotics may play an important role in managing the symptoms of restless leg syndrome (RLS).

Some studies have shown that consuming probiotic bacteria helps to reduce the frequency and severity of RLS symptoms. It also reduces pain related to movement disorder activity, improves sleep quality and decreases daytime fatigue. 

In addition, probiotics seem to boost gut health which helps increase the body’s immune system response against RLS-associated pathogens. Overall, these findings suggest that taking a supplement with probiotics may be one way to manage RLS more effectively.

Physician’s Choice Probiotics 60 Billion CFU – 10 Diverse Strains Plus Organic Prebiotic

Physician's Choice Probiotics
Physician’s Choice Probiotics

Chromium picolinate

Chromium picolinate is a supplement that has been shown to help manage the symptoms of restless leg syndrome (RLS). Chromium Picolinate is a mineral that plays an important role in carbohydrate metabolism and insulin regulation. It has also been associated with improved blood sugar control and reduced weight gain in people with diabetes.

Best Naturals Chromium Picolinate 1000mcg 

Best Naturals Chromium Picolinate
Best Naturals Chromium Picolinate

Some studies have found that chromium picolinate can improve the symptoms of RLS by improving sleep quality and reducing muscle pain. Other research suggests that it may reduce inflammation, improve nerve function, and promote better wound healing.


In addition to vitamins, some common herbal ingredients that are often used to treat Restless Leg Syndrome include:

lavender oil

Lavender oil has been traditionally used to treat a wide range of conditions, including anxiety disorders, stress relief, and insomnia. It has also been shown to help reduce the severity and frequency of RLS symptoms in some patients. In fact, one study found that people who took lavender oil supplements reported significantly lower levels of restless leg syndrome than those who didn’t take it.

Lavender works by reducing inflammation throughout the body; others believe that they have antidepressant properties which relieve tiredness and encourage relaxation. However, there is still much research need on this topic before we can say with certainty howlavender oil helps manage restless leg syndrome symptoms.

Cliganic USDA Organic Lavender Essential Oil – 100% Pure Natural Undiluted

Cliganic USDA Organic Lavender Essential Oil
Cliganic USDA Organic Lavender Essential Oil

Ginger root extract

Restless leg syndrome (RLS) is a condition that causes uncomfortable sensations in the legs, usually during the night. It can be very frustrating and disruptive to everyday life. Fortunately, there are many ways to manage RLS symptoms. One of these methods is using ginger root extract supplements.

Ginger is a powerful herb with multiple benefits for both health and wellness. It has been used traditionally as an herbal remedy for various conditions, including RLS. In fact, research shows that ginger root extracts can help improve sleep quality and reduce bothersome leg movements during the night by improving nerve function and reducing inflammation levels in the body.

Ginger Root Capsules 1500 mg

Ginger Root Capsules
Ginger Root Capsules

Bacopa monnieri extract

Bacopa monnieri Extract contains compounds known as b hailides, which have neuroprotective and anti-inflammatory properties. These properties may help improve nerve function and reduce inflammation in the brain, leading to better symptom management. Bacopa has been shown to improve cognitive function and reduce inflammation, both of which may contribute to its effectiveness for RLS.

Himalaya Organic Bacopa/Brahmi, 60 Caplets for Mental Alertness, Cognitive Health & Memory Support

Himalaya Organic Bacopa/Brahmi
Himalaya Organic Bacopa/Brahmi


Chamomile  has been used for centuries as a natural treatment for a variety of ailments, including restless leg syndrome (RLS). Chamomile is an incredibly versatile herb that has many benefits for both the body and mind. Here are four reasons why chamomile might help manage the symptoms of RLS: 

  1. Chamomile helps to relax muscles and relieve tension headaches. This relaxation effect can be effective in relieving tension related to RLS symptoms, such as pain, heaviness, anxiety, and insomnia. 
  1. Chamomile is known to improve moods by boosting serotonin levels in the brain. Serotonin is commonly responsible for regulating emotions and promoting sleepiness/apnea regulation. Higher serotonin levels may lead to more restful sleep in people with RLS due to improved anxiety relief and reduced muscle spasms associated with restless legs syndrome (RLS). 
  1. Chamomile contain flavonoids which are believed to promote overall health by helping reduce inflammation throughout the body . Inflammation has been linked with several chronic conditions – including RLS – so reducing inflammation could be beneficial in managing this condition.

We recommend taking chamomile in the form of a relaxing tea before bed. 

 FGO Organic Chamomile Tea Bags

FGO Organic Chamomile Tea Bags
FGO Organic Chamomile Tea Bags

Gotu kola leaves

Gotu kola (Centella asiatica) is a shrub found in tropical and subtropical regions of the world. It has been used for centuries to treat a variety of ailments, including restless leg syndrome (RLS).

Research suggests that Gotu kola leaves can help improve symptoms such as restlessness, discomfort, and increased urination. In addition, it is thought that the tea may also be helpful in reducing inflammation and pain associated with RLS.

Nature’s Way Premium Herbal Gotu Kola Herb

Nature Way Premium Herbal Gotu Kola Herb
Nature Way Premium Herbal Gotu Kola Herb


Ashwagandha is a popular herb that has been used for centuries in India to manage the symptoms of restless leg syndrome (RLS). Ashwagandha contains compounds called anxiolytic and sedative agents, which help to improve the sleep quality of people with RLS. Additionally, ashwagandha helps to reduce anxiety and stress levels, promotes better cognitive function, and reduces inflammation. Taken as prescribed by a healthcare professional, ashwagandha can be an effective treatment option for those with RLS.

Organic India Ashwagandha Herbal Supplement – Stress Response Support

Organic India Ashwagandha Herbal Supplement
Organic India Ashwagandha Herbal Supplement

What do you need to know before starting a herbal treatment for RLS?

Be sure to consult with a health professional or naturopath who can assess your specific symptoms and recommend an effective course of treatment.  They will be able to best tell you what combination of the above list will work best for you.

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